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VIDEO: Warriors’ Steve Kerr on Klay Thompson’s big game in 113-105 win versus L.A. Clippers

first_imgThe Golden State Warriors didn’t need their two-time league MVP Stephen Curry to have a big game to take care of the Los Angeles Clippers on Sunday. For many teams in the NBA that might be an issue but not when you have Kevin Durant and Klay Thompson to pick up the slack. Durant and Thompson combined for 65 of the team’s points in the 113-105 win.Thompson was particularly hot early scoring on his first seven attempts. He would end the game with 32 points. Klay’s hot hand had a positive effect …last_img read more

Sharks clear salary cap space, trade Justin Braun to Flyers

first_imgSAN JOSE — Clearing some space under NHL’s salary cap for next season, the Sharks traded defenseman Justin Braun to the Philadelphia Flyers on Tuesday for a second-round selection (41st overall) in this weekend’s NHL Draft and a third-round pick next season.Braun is set to make $3.8 million next season, the final one of a five-year, $19 million deal he signed in Sept. 2014. Per TSN’s Pierre LeBrun, the Sharks are not retaining any of Braun’s salary in the trade.With a handful of roster …last_img read more

In Praise of Fat

first_imgWell, great balls of fat.  Cells have spherical globs of lipid (fat) molecules that never had gotten much attention nor respect.  They have been called lipid droplets, oil bodies, fat globules and other names suggesting they were just the beer bellies of the cell.  Not any more.  Scientists have been taking a closer look at these globs and are finding them to be dynamic, functional sites of critical metabolic activity.  No longer are they bags of superfluous undesirable molecules: they have been promoted to essential organelles, named adiposomes.    Mary Beckman introduced two papers in Science with a summary of the new discoveries.1 Whatever their name, these intracellular blobs of triglycerides or cholesterol esters, encased in a thin phospholipid membrane, are catching the attention of more and more biologists.  It turns out these lively balls of fat have as many potential roles within cells and tissues as they have names.  Pockmarked with proteins with wide-ranging biochemical activities, they shuffle components around the cell, store energy in the form of neutral lipids, and possibly maintain the many membranes of the cell.  The particles could also be involved in lipid diseases, diabetes, cardiovascular trouble, and liver problems.   (Emphasis added in all quotes.)Beckman discussed several recent findings demonstrating what happens when fat regulation by adiposomes is disrupted.  Since there is still much to be learned about adiposomes, Beckman mainly teased the readers with the possibilities that lie ahead.  She quoted one biologist who called the biology of lipid droplets “immense and untapped.”    A Perspectives paper in the same issue by Stuart Smith introduced new findings about the machines that make fat.2  He summarized a paper by Maier, Jenni and Ban revealing, in unprecedented detail, the structure of mammalian Fatty Acid Synthase (FAS),3 and another by the same authors plus Leibundgut about the comparable FAS machine in fungi.4  The former looks somewhat like a flying saucer; the latter, like a wheel with spokes from the top, or a complex cage from the side.  The diagrams of these machines point out “active sites” and “reaction chambers” where complex molecules are assembled in a specific sequence.  The machines apparently have moving parts.  The conclusion of the mammalian FAS paper hints how everything must be done in order and with the right specifications:The overall architecture of mammalian FAS has been revealed by x-ray crystallography at intermediate resolution.  The dimeric [two-part] synthase adopts an asymmetric X-shaped conformation with two reaction chambers on each side formed by a full set of enzymatic domains required for fatty acid elongation, which are separated by considerable distances.  Substantial flexibility of the reaction chamber must accompany the handover of reaction intermediates during the FAS cycle, and further conformational transitions are required to explain the presence of alternative inter- and intrasubunit synthetic routes in FAS.  The results presented here provide a new structural basis to further experiments required for a detailed understanding of the complex mechanism of mammalian FAS.Even for the fungal machine, the authors spoke of the “remarkable architectural principles” it exemplifies.  It’s a whole new world of fat.  Let that go to your understanding, not to your waist.1Mary Beckman, “Great Balls of Fat,” Science, 3 March 2006: Vol. 311. no. 5765, pp. 1232 – 1234, DOI: 10.1126/science.311.5765.1232.2Stuart Smith, “Architectural Options for a Fatty Acid Synthase,” Science, 3 March 2006: Vol. 311. no. 5765, pp. 1251 – 1252, DOI: 10.1126/science.1125411.3Timm Maier, Simon Jenni, Nenad Ban, “Architecture of Mammalian Fatty Acid Synthase at 4.5 � Resolution,” Science, 3 March 2006: Vol. 311. no. 5765, pp. 1258 – 1262, DOI: 10.1126/science.1123248.4Simon Jenni, Marc Leibundgut, Timm Maier, Nenad Ban, “Architecture of a Fungal Fatty Acid Synthase at 5 � Resolution,” Science, 3 March 2006: Vol. 311. no. 5765, pp. 1263 – 1267, DOI: 10.1126/science.1123251.The closer they look, the more wondrous the cell gets.  Who would have thought that blobs of fat would contain machinery with moving parts and reaction chambers?  Who would have imagined their surfaces would be covered with complex proteins that regulate the production inside?  Who would have realized that fat was so important, the cell had complex assembly plants to build it?  Fat is almost a mild cussword in our vocabulary, but it is another class of molecular building blocks we couldn’t live without.  Fats, sugars, proteins and nucleic acids all work together in life, from humans to lowly fungi.  Each class of molecules has immense variety, each is essential, and each is manufactured to spec by precision machinery.  What a wonderful post-Darwinian world.(Visited 15 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

2015 Ohio State Fair Outstanding Market Exhibitors

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Kaci Way, from Wayne County, was the first place Market Barrow Outstanding Market Exhibitor. Kelsey Vollrath, from Clark County, was second place and Hunter Frobose, from Wood County, was third. Photo by Alyssa Muhlenkamp. Curtis Harsh, from Delaware County, was the first place Market Beef Outstanding Market Exhibitor. Dawson Osborn, from Highland County, was second place and Allison Davis, from Carroll County, was third. Photo by Alyssa Muhlenkamp. Curtis Harsh, from Delaware County, was the first place Breeding Beef Outstanding Market Exhibitor. Samantha Wallace, from Sandusky County, was second and Jennifer Siegel, Crawford County, was third. Photo by Alyssa Muhlenkamp. Chas Grover, from Fayette County, was the first place Market Goat Outstanding Market Exhibitor. Tiffany Sunday, from Pickaway County, was second and Jacob Roeth, from Miami County, was third. Photo by Alyssa Muhlenkamp. Margo Sturgis, from Wayne County, was the first place Market Lamb Outstanding Market Exhibitor. Bailee Amstutz, Union County, was second and Justin Howell, from Knox County, was third. Photo by Alyssa Muhlenkamp.last_img read more

Should You Use Vintage Lenses on Your Next Project?

first_imgShows That Use Vintage GlassImage via FX.Vintage lenses have made their way into everything from independent films to TV Shows to commercials to Hollywood blockbusters. Many of today’s best DPs are relying on the image qualities and characteristics that vintage glass creates for digital sensors. One of the most prominent and critically well-received shows using vintage glass is Atlanta, which combines an ARRI Amira with Kowa Cine Prominar lenses. Also, the FX show Baskets used vintage Cooke Speed Panchros to create a unique look, and Spike Jonze used vintage Canon K35s on HER.Manufacturer’s ApproachLens manufacturers have even been embracing this unique market shift toward vintage lenses. A notable example is the ARRI Alexa 65, which the company pairs with a set of vintage 765 lenses to complement the camera’s sensor.Image via ARRI.Further, due to a very sharp increase of demand, Cooke has recently started remanufacturing their well-known and well-respected Cooke Speed Panchro Lenses. These lenses first appeared in the 1920s, and at one point, were shooting 90 percent of all 16mm films.As images become increasingly sharper with ever-higher degrees of detail and resolution, vintage lenses will continue to lend more filmic and cinematic looks to digital images. So, if you need a unique look for your next project, vintage glass may be the perfect solution.Looking for more articles on lenses? Check these out.Hot Dog! You Can Now Make AR Lenses for Snapchat in Lens StudioGear Review: the Leica Summicron-C Series of LensesWorking with Vintage Lenses on Modern Cameras10 Things to Know About Shooting with Vintage LensesUsing Vintage Film Lenses on Micro 4/3 Cameras Considering a signature look for your next project? Let’s take a look at why the perfect set of vintage cinema lenses may be just the thing you need.Cover image via Shutterstock.Vintage Lenses are a hot ticket among cinematographers. The way these vintage lenses complement digital sensors has made them invaluable, and the characteristics behind these lenses — as well as how they resolve today’s digital images — means the resurgence in popularity won’t decline anytime soon.Digital camera sensors today are nearly flawless. They can capture immense detail at extremely high resolutions. However, this degree of detail and resolution can, in some cases, create less-than-flattering images. As a result, cinematographers have gone looking for ways to soften the edges of their digital images. Some, for example, rely on camera diffusion. (I’ve seen many cinematographers use ⅛ Blackmagic filtration to get the look they want out of digital equipment.)However, vintage lenses have risen to the surface as the best tool to complement digital sensors. The characteristics they bring to today’s digital sensors have been a perfect marriage of digital and analog technology. This lens test by The Vintage Cinema Camera Lens Library goes into detail about what you can expect from a vintage lens — and how they differ from each other.last_img read more